アディポネクチンの心臓保護は,心筋不全/再注血後の酸化/窒素性ストレスの軽減を伴う
Ling Tao1, Erhe Gao, Xiangying Jiao
1Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Circulation
|March 7, 2007
まとめ
アディポネクチンは,酸化ストレスと炎症を軽減することによって,心臓をイシュケミア/再注射損傷から保護します. この研究は,アディポネクチニンを明らかにしています.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 分子生物学は分子生物学である.
背景:
- アディポネクチンのレベルは,2型糖尿病患者で低下しています.
- アディポネクチンのレベルは,心筋梗塞症のリスクと逆相関する.
研究 の 目的:
- 筋動脈不全/再注射損傷に対するアディポネクチンの保護効果のメカニズムを解明する.
主な方法:
- 心筋梗塞のサイズ,アポトーシス,酸化ストレスマーカーの比較,アディポネクチンノックアウトと,イシュケミア/再注射を受けた野生型のマウス.
- 誘導性酸化窒素合成酵素 (iNOS) とgp91 (phox) タンパク質発現の評価.
- アディポネクチン球体領域の投与効果の評価.
主要な成果:
- アディポネクチン欠乏症は,心筋閉塞と心臓発作の大きさを著しく高めました.
- アディポネクチン欠乏症のマウスで酸化窒素 (NO),超酸化物,ペロキシニトリトの形成の増加.
- アディポネクチンの投与は,イシュケミア/再輸血誘発の酸化ストレスを軽減し,心臓損傷から保護しました.
結論:
- アディポネクチンは,イシュケミア/リパーフュージョンによる損傷に対する自然な心臓保護分子です.
- アディポネクチンは,iNOSとNADPH酸化酵素を阻害し,酸化性/窒素性ストレスを軽減します.
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