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An Acupoint Catgut-embedding Therapy for Treating Obesity
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二次性脂質不全症. 二次性脂質不全症. 二次性脂質不全症. 二次性脂質不全症. 二次性脂質不全症. 臨床実務における薬物による不注意な影響
Y Henkin1, J A Como, A Oberman
1Division of General and Preventive Medicine, University of Alabama, Birmingham 35294.
JAMA
|February 19, 1992
まとめ
特定の薬は,血液の脂質と脂質タンパク質のレベルに影響を与え,一部の薬は潜在的に心血管疾患のリスクを増加または減少させる可能性があります. 医師は,患者のケアにおいて,これらの薬物効果を考慮すべきである.
科学分野:
- 薬理学 薬理学とは
- 心血管医学 心血管医学
- 脂質代謝 脂質代謝とは
背景:
- 血液の脂質と脂質タンパク質のプロファイルにおける薬物誘発による変化は,重要な臨床的考慮事項です.
- これらの効果を理解することは,心血管疾患のリスクを管理する上で極めて重要です.
研究 の 目的:
- 一般的に処方される医薬品に関する文献を体系的にレビューし,血液の脂質および脂質タンパク質レベルへの影響を検討する.
- 潜在的にアテロゲン性および抗アテロゲン性薬剤のクラスを特定する.
主な方法:
- MEDLARS II,MEDLINE,Index Medicusを用いて,1975年から1990年にかけての英語記事に関する包括的な文献検索を行いました.
- 研究の設計と結果の重要性に基づいて500以上の論文を掲載した.
- 薬による脂質,リポタンパク質,アポタンパク質の変化の定量分析.
主要な成果:
- 潜在的に有害な薬には,プロゲスタジェニック/アンドロゲン性を持つステロイドホルモン,レチノイド,サイクロスポリンA,フェノチアジンが含まれます.
- 潜在的に抗アテロゲン性薬には,エストロゲン性ステロイドホルモン,抗発作薬,ビグアニド,ケトコナゾール,アミノサリチル酸が含まれます.
- コルチコステロイドと経口エストロゲンは,リポプロテインコレステロールとトリグリセリドのレベルを上昇させる可能性があります.
結論:
- リポプロテイン代謝の薬物誘発による変化は,臨床実務に意味を持っています.
- これらの薬物効果の長期的な影響については,さらなる調査が必要である.
- 医師は,患者を管理する際に,薬物によって引き起こされる脂質変化を考慮する必要があります.
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