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関連する概念動画

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium08:45

Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium

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Gastric patient-derived organoids find increasing use in research, yet formal protocols for generating human gastric organoids from single-cell digests with standardized seeding density are lacking. This protocol presents a detailed method for reliably creating gastric organoids from biopsy tissue obtained during upper...
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Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

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Laparoscopy-endoscopy cooperative surgery is appropriate for the treatment of gastric gastrointestinal stromal tumors less than 5 cm in size. It can achieve the respective advantages of endoscopic and laparoscopic surgeries while avoiding their...
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Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization08:16

Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization

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Multiplex in situ hybridization (ISH) was employed to simultaneously visualize the transcripts for two G protein-coupled receptors and one transcription factor in the entire vagal ganglionic complex of the adult mouse. This protocol could be used to generate accurate maps of the transcriptional profiles of vagal afferent...
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One-anastomosis Gastric Bypass (OAGB) in Rats08:16

One-anastomosis Gastric Bypass (OAGB) in Rats

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This protocol is for the performance of one-anastomosis gastric bypass (OAGB) on rat. The operator performs a long and tubular-stapled gastric pouch followed by hand-sewn anastomosis. For this model, the operator reproduces the same ratio between biliopancreatic and common limb in humans; therefore, the biliopancreatic limb measures 35 cm.
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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test12:24

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

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Determination of gastric emptying with a non-invasive [13C]-octanoic acid breath test for tracking gastroparesis in female NOD LtJ...
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Roux-en-Y Gastric Bypass Operation in Rats07:37

Roux-en-Y Gastric Bypass Operation in Rats

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Numerous studies using gastric bypass rat models have been recently conducted to uncover the underlying physiological mechanisms of Roux-en-Y gastric bypass operations. This article aims to demonstrate and discuss the technical and experimental details of our published gastric bypass rat model to understand advantages and limitations of this experimental...
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関連する実験動画

Updated: Jan 31, 2026

One-anastomosis Gastric Bypass OAGB in Rats
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老化,肥満,カロリー制限

Luigi Fontana1, Samuel Klein

  • 1Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, Mo 63110, USA. lfontana@im.wustl.edu

JAMA
|March 8, 2007
PubMed
まとめ
この要約は機械生成です。

大人のカロリー制限は,ネズミに似た代謝効果を示していますが,人間の長寿のための最適な摂取量は不明です. 過剰な制限は,栄養失調や有害な影響を引き起こす可能性があります.

さらに関連する動画

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
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Roux-en-Y Gastric Bypass Operation in Rats
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Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

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関連する実験動画

Last Updated: Jan 31, 2026

One-anastomosis Gastric Bypass OAGB in Rats
08:16

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Published on: November 10, 2018

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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
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Roux-en-Y Gastric Bypass Operation in Rats
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科学分野:

  • ゲロントロジーはゲロントロジーの学科です.
  • 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
  • メタボリック・ヘルス (代謝の健康)

背景:

  • 過剰なカロリー摂取による肥満は慢性疾患のリスクを高め,平均寿命を短縮します.
  • 適切な栄養素を含むカロリー制限 (CR) は,ネズミの寿命を延ばし,病気のリスクを下げる.

研究 の 目的:

  • カロリー制限の生理学的および臨床的影響を評価し,栄養素の適切な摂取を図る.

主な方法:

  • PubMedの包括的な文献検索,ゲロントロジージャーナル,および参照リスト.
  • 流行病学,症例対照,ランダム化対照試験を含む.
  • ピアレビュー,サンプルサイズ,客観性,バイアスの最小化に基づくレビューされたレポートの品質評価.

主要な成果:

  • 成人ヒトのCRは,CRのネズミやサルに似た代謝,ホルモン,炎症的適応を誘発する.
  • これらの適応には,糖尿病,心臓血管疾患,そして潜在的に癌の危険因子の減少が含まれます.
  • 過剰なカロリー制限は,栄養失調と有害な臨床結果につながります.

結論:

  • 大人のカロリー制限は,有益な代謝,ホルモン,機能の変化を促進します.
  • 人間の健康と長寿のために最適なカロリー摂取量と体脂肪は,まだ決定されていません.
  • 適度なCRは,痩せた個体などの特定の集団にリスクをもたらす可能性があります.