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Updated: May 4, 2026

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
10:46

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: November 3, 2011

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Nkx2-5/Bmp2/Smad1のネガティブなフィードバックループは,心臓の祖先の仕様と増殖を制御します

Owen W J Prall1, Mary K Menon, Mark J Solloway

  • 1Victor Chang Cardiac Research Institute, Sydney 2010, Australia.

Cell
|March 14, 2007
PubMed
まとめ

Nkx2-5はBmp2/Smad1のシグナル伝達を抑制して,心臓の先駆体増殖と流出管の発達を制御する. このフィードバックループは,正常な心臓形成に不可欠であり,先天性心疾患 (CHD) の標的となる可能性があります.

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