非活性X染色体とのBRCA1のコミュニケーションのさらなる証拠
Daniel P Silver1, Stoil D Dimitrov, Jean Feunteun
1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Cell
|March 14, 2007
まとめ
乳がんと卵巣がんを抑制するBRCA1遺伝子は,不活性X染色体 (Xi) の調節に役割を果たしています. 新しい研究がBRCA1を裏付けている.
科学分野:
- * 分子生物学について
- * 癌遺伝学について
- * エピジェネティクスと遺伝子調節
背景:
- * BRCA1は,DNA修復と細胞サイクルチェックポイント制御に関与する腫瘍抑制遺伝子として知られています.
- *以前の研究では,女性細胞におけるBRCA1と不活性X染色体 (Xi) の間の潜在的相互作用が示唆されていた.
- * 最近の研究では,この相互作用が疑問視されており,さらなる調査が必要となっている.
関連する概念動画
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The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
X-inactivation
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...


