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Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis
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心臓組織におけるGタンパク質による信号伝達
J W Fleming1, P L Wisler, A M Watanabe
1Department of Medicine, Indiana University School of Medicine, Indianapolis.
Circulation
|February 1, 1992
まとめ
Gタンパク質は,ホルモンに対する心臓の反応と神経系にとって極めて重要です. 彼らの機能障害は,潜在的に遺伝的欠陥に関連した心血管疾患に寄与する可能性があります.
科学分野:
- 心臓病学 心臓病学
- 分子生物学は分子生物学である.
- バイオケミストリー バイオケミストリー
背景:
- Gタンパク質は,心筋細胞のシグナル伝達において不可欠なリンクとして機能する.
- 彼らはカテキオラミンと自律神経系の活動に対する心臓の反応を媒介する.
研究 の 目的:
- 心血管生理学と病理生理学におけるGタンパク質の役割を調査する.
- 心血管疾患における潜在的なGタンパク質関連の欠陥を調査する.
主な方法:
- 分子生物学的および再結合DNA技術を活用する.
- トランスジェニック動物モデルを用いて,Gタンパク質の機能と遺伝子用量を研究する.
- 疾患モデルにおける特定の遺伝子用量に対する生理学的機能の関係.
主要な成果:
- Gタンパク質は,神経伝達物質とホルモンの相互作用と心筋膜受容体との間で不可欠な役割を果たします.
- 証拠によると,Gタンパク質の機能不全は,心血管病理生理学に関連していることを示唆しています.
- 心血管疾患は,Gタンパク質関連の欠陥と関連している可能性があります.
結論:
- Gタンパク質は,心臓の自律的およびホルモンシグナル伝達に不可欠です.
- 機能不全のGタンパク質は,心血管疾患に寄与する可能性が高い.
- 先進的な技術により,心血管疾患を特定のGタンパク質の欠陥まで追跡することができます.
関連する概念動画
G-protein Coupled Receptors
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G-protein Coupled Receptors
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
GPI Anchoring of Proteins in the ER Membrane
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
G Protein-coupled Receptors
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G-Protein Gated Ion Channels
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Sensory organs,...
G Protein-coupled Receptors
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

