発作後の地域性麻痺が持続したにもかかわらず,全体的な機能回復のメカニズム
W E Lawrence1, W L Maughan, D A Kass
1Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Md.
Circulation
|February 1, 1992
まとめ
冠動脈閉塞後の再輸は,持続的な地域的機能不全にもかかわらず,全般的な心臓機能を完全に回復させた. この回復は,反射的変化ではなく,主として受動的な硬さの変化と活性機能の部分的な回復によるものでした.
科学分野:
- 心血管生理学 心血管の生理学
- 心筋リパーフューゼーション傷害 心筋リパーフューゼーション傷害 心筋リパーフューゼーション
- 心臓のメカニズム 心臓のメカニズム
背景:
- 冠動脈閉塞と再注血後の全機能回復のメカニズムを調査する.
- 再輸血後の地域と世界の心臓機能の不一致を理解する.
研究 の 目的:
- リパルフュージョン後の地域的機能不全にもかかわらず,完全な世界的な心臓回復の背後にあるメカニズムを解明する.
- 左心室の圧力-体積,圧力-厚さ関係に対する再注入の影響を分析する.
主な方法:
- 冠動脈閉塞の犬における圧力-体積と圧力-厚さの関係を同時に測定する.
- ソノミクロメトリーを用いた地域壁の厚さの評価.
- 全身シストリック機能の評価は,エンドシストリック圧力-体積関係 (ESPVR) による.
主要な成果:
- 冠動脈閉塞は,地域的な薄くなり,全体的な機能不全を引き起こしました.
- リパルフュージョンの後,地域的な濃縮は損なわれ続けましたが,グローバル機能は完全に回復しました.
- 再輸液は,受動的な硬化を変化させ,活性機能を回復することにより,室内シストリックパフォーマンスを正常化しました.
結論:
- 再注入は,地域壁の動きだけで予測されるよりも大きな機能的利点を提供します.
- この研究では,回復のための重要なメカニズムとして,変化した受動的な硬化と部分的な活性機能の回復を特定しています.
- この発見は,再注射後の地域機能不全に関する伝統的な解釈に異議を唱えている.
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