動脈の高酸素圧力が機能,血流の分布,および缺血性心筋の代謝に及ぼす影響
B A Cason1, J A Wisneski, R A Neese
1Department of Anesthesiology, University of California, San Francisco.
Circulation
|February 1, 1992
まとめ
高レベルの酸素は,イシュケミア中の心臓の機能を改善します. 動脈高酸素症は,血動脈の収縮機能と血流を向上させ,同時に,缺血性心筋の糖分代謝を減少させた.
科学分野:
- 心臓病学 心臓病学
- 生理学 生理学とは
- バイオケミストリー バイオケミストリー
背景:
- 酸素吸入療法は,急性心筋動脈不全のために使用されていますが,低酸素症なしでの利点については議論されています.
- この研究では,大動脈高酸素症が豚のモデルで心筋不全症に及ぼす影響を調査した.
研究 の 目的:
- 急性低血流性心筋不全症の間,動脈高酸素症が地域性心筋収縮機能,血流分布,および糖分代謝に及ぼす影響を決定する.
- 動脈中の酸素濃度の上昇が,不血性疾患における心臓機能と代謝プロフィールを改善するかどうかを評価する.
主な方法:
- 豚のサブエンドカーディアル心筋動脈不全のモデルを使用し,左前部下降冠動脈の流れを制御しました.
- 動脈の酸素部分圧 (PO2) は,インスピレーションされた酸素濃度 (FIO2) を介して操作されました.
- 地域性心筋機能 (音波測定),血流 (微小球) および代謝 (炭素同位素で標識された基板) は,ノルモキシアおよびハイパーオキシアの下で測定されました.
主要な成果:
- 筋心臓のイシュケミアにより,シストリック収縮と内心臓の血流が低下した.
- 冠動脈高酸素症は,血栓収縮と心臓内血流を大幅に増加させた.
- ハイパーオキシアは,内心:表心流量比を改善し,乳糖の吸収と乳酸の生産を低下させた.
結論:
- 急性低血流性心筋不全症の間における動脈PO2の上昇は,心筋機能と血流の分布を改善する.
- 高濃度の酸素は,発血性心筋内におけるグリコリチス代謝を低下させる.
- 収縮機能の観察された改善は,心下髄下血流の強化と相関しています.
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