関連する実験動画
Updated: May 4, 2026
20:16
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
Published on: February 1, 2018
8.8K
小児急性リンパ性白血病の後に最初のイベントとして二次性腫瘍の累積的発生率
Nobuko Hijiya1, Melissa M Hudson, Shelly Lensing
1Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA. nobuko.hijiya@stjude.org
JAMA
|March 22, 2007
まとめ
幼児期急性リンパ性白血病の生存者における二次がんのリスクは,30年以上にわたって大幅に増加し,攻撃的な腫瘍の有意な増加があります. 生存者にとって,生涯の監視は極めて重要です.
科学分野:
- 小児腫瘍学 小児腫瘍学
- 癌の流行病学について
- 長期的ながん生存率
背景:
- 幼児の急性リンパ性白血病 (ALL) の治療後の15〜20年以上の二次がん発生に関するデータは限られている.
- 長期的なリスクを理解することは,すべての生存者の結果を改善するために不可欠です.
研究 の 目的:
- 30年以上の小児ALL患者における二次性腫瘍の累積的発生率を決定する.
- このコホートにおける遅発腫瘍の種類とパターンを特徴付ける.
主な方法:
- 1962年から1998年の間にALL治療を受けた2,169人の小児患者の遡及的分析.
- 追跡期間の中央値は18.7年 (範囲は2.4~41.3年) でした.
- 一般人口と比較した累積発生率と標準発生率の計算.
主要な成果:
- ALL治療の30年後の二次性腫瘍の累積発生率は10.85%に達しました.
- 髄膜腫と基礎細胞癌を除くと,30年間の罹患率は6.27%で,一般人口より13.5倍増加しました.
- 骨髄性悪性腫瘍,脳腫瘍,癌の有意な増加が観察され,攻撃的な腫瘍は予想以上に頻繁に発生しました.
結論:
- 2次性腫瘍の発生率は,小児ALL治療の30年後に着実に上昇しています.
- 攻撃的な悪性腫瘍を含む遅発の腫瘍は,実質的な長期的なリスクをもたらす.
- ALLの生存者は,二次がんの発症をモニタリングし管理するために,生涯の追跡が推奨されます.
関連する概念動画
02:21Cancers Originate from Somatic Mutations in a Single Cell
12.6K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.6K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:20The Retinoblastoma Gene
3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
01:27Disorders of Leukocytes
2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
01:16Primary Lymphoid Organs
9.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
9.6K
01:15Secondary Lymphoid Organs
7.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.2K