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Updated: May 11, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

抗菌多剤耐性の分子メカニズム

Michael N Alekshun1, Stuart B Levy

  • 1Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. michael.alekshun@spcorp.com

Cell
|March 27, 2007
PubMed
まとめ

移動性遺伝要素や排気ポンプのような内在的なメカニズムによって引き起こされる多剤耐性細菌の増加は,世界中で抗生物質の有効性を損なう. これは重大な公衆衛生上の課題となり,治療の失敗や広範囲にわたる感染症につながる.

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Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System05:06

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Overview
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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Clinical Significance of Antibiotic Resistance

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