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Updated: Jan 9, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
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アテロゲン性不脂血症または高コレステロール血症の患者における強力で選択的なPPAR-αアゴニストの効果:ランダム化比較試験2件

Steven E Nissen1, Stephen J Nicholls, Kathy Wolski

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA. nissens@ccf.org

JAMA
|March 27, 2007
PubMed
まとめ

強力なPPAR-αアゴニストであるLY518674は,トリグリセリドを効果的に低下させ,脂質不全や高コレステロール血症の患者でHDL-Cを上昇させた. しかし,LDL-Cと血清クレアチニンも増加し,フェノフィブラートと同様の安全性に関する懸念を引き起こしました.

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