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Updated: Jul 16, 2026

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

Hisタグのタンパク質のリガンドの急速な交換のための境界状態の残留二極結合

Ronald D Seidel1, Tiandi Zhuang, James H Prestegard

  • 1Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602-4712, USA.

Journal of the American Chemical Society
|March 28, 2007
PubMed
まとめ

この研究は,リガンド-タンパク質相互作用の研究のための残留二極結合 (RDC) を改善するための新しい方法を示しています. このテクニックは,境界状態データを強化し,薬物設計を支援し,タンパク質の機能を理解します.

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Ligand Binding and Linkage

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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
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Cooperative Allosteric Transitions01:58

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