中心交感動脈と磁気共鳴画像で決定された左心室質量の関係 基本的高血圧における左心室質量
Joanna Burns1, Mohan U Sivananthan, Stephen G Ball
1Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Circulation
|March 29, 2007
まとめ
交感神経の活動は,高血圧における左心室縮 (LVH) と関連しています. 交感性活性化の増加は,左心室質量 (LVM) の増加と相関し,LVHの発症におけるその役割を支持する.
科学分野:
- 心臓病学 心臓病学
- 高血圧の研究 高血圧の研究
- 神経心臓病学 神経心臓病学
背景:
- 交感神経系の過剰活動は,左心室縮症 (LVH) 発症の既知の要因である.
- 交感性活性化と左心室質量 (LVM) の間の正確な関係は,様々な動脈圧で不明のままである.
- 本研究では,同情活動と,高血圧患者および高血圧患者で,同情活動と,高血圧患者および高血圧患者で,高血圧患者と,高血圧患者で,高血圧患者と,高血圧患者で,高血圧患者と,高血圧患者で,高血圧患者で,高血圧患者と,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で,高血圧患者で
研究 の 目的:
- 高血圧患者における交感性活性化と左心室質量 (LVM) の関係を決定する.
- シンパティック神経の活動とLVMを,LVHと無LVHの患者と,正常な対照群と比較するために.
- 交感活動,LVM,動脈血圧の相関性を評価する.
主な方法:
- LVH (LVH[-]) のない高血圧患者24人,LVH (LVH[+]) の患者25人,対照患者24人を比較した.
- 多ユニットおよび単ユニットの記録を使用して,定量化された静止筋肉の交感神経活動 (SNA).
- 測定された左心室質量 (LVM) は,心臓磁気共鳴画像を用いて,体表面積 (LVM指数) にインデックスされています.
主要な成果:
- LVM指数は,LVH[+] (91g/m2) で,LVH[-] (67g/m2) と対照群 (57g/m2) よりも,LVH[+] (91g/m2) で著しく高かった.
- シンパシー活動は,対照群 (39バースト/100ビート) と比較して,LVH[-] (53バースト/100ビート) とLVH[+] (66バースト/100ビート) で高かった.
- 強い正の相関関係 (r=0.76) は,高血圧群ではSNAとLVM指数の間に見られたが,対照群ではそうではなかった. BP-SNAまたはBP-LVMとの一貫した関係は見られなかった.
結論:
- 中央交感性活性化は,ヒトの高血圧における左心室縮 (LVH) と関連している.
- これらの発見は,LVHの病原性における交感性過剰活性の役割を強化しています.
- 血圧だけでは,この文脈で同情活動やLVMを一貫して予測することはできません.
関連する概念動画
Pulse
4.0K
The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
4.0K
Pulse
2.5K
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
The pulse serves as a clinical...
2.5K
Mitral Regurgitation I: Introduction
1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Mitral Stenosis I: Introduction
1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K
Heart Failure II: Pathophysiology
2.1K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
2.1K
Hypertension II: Pathophysiology
1.8K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.8K


