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脳卒中と短期間性血栓不全の二次予防:より多くの血小板抑制が解決策ですか?
1Cardiovascular Division, Department of Medicine, Brigham & Women's Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA 02139, USA. jliao@rics.bwh.harvard.edu
Circulation
|March 29, 2007
まとめ
心臓病に対する二重抗血小板治療は,再発性脳卒中を予防しないため,二次脳卒中予防は非常に重要です. 組み合わせ療法では,二次性脳卒中予防のための最適な血小板阻害を提供します.
科学分野:
- 神経科学は神経科学である.
- 心血管医学 心血管医学
- 薬理学 薬理学とは
背景:
- 再発性脳血管疾患は,米国における年間脳卒中の有意な割合を占めています.
- 二次性脳卒中予防は,脳卒中または一時的な性発作 (TIA) の病歴を有する患者の主要な管理目標です.
研究 の 目的:
- 二次性脳卒中予防のための抗血小板治療の有効性と安全性を評価する.
- 発血性脳卒中患者のための最適な抗血小板戦略を決定する.
主な方法:
- 卒中患者の抗血小板治療に関する最近の臨床試験のレビュー.
- 脳血管疾患における抗血小板効果と心血管疾患における抗血小板効果の比較.
主要な成果:
- 冠動脈症候群に有益な二重抗血小板治療は,二次性脳卒中予防を提供していません.
- 脳卒中患者は,異なる病因と出血のリスクにより,異なる抗血小板療法が必要になる可能性があります.
- 脳卒中予防のための最適な血小板抑制には,増加した出血を避けるためのバランスが含まれる.
結論:
- 動脈不全性脳卒中の抗血小板療法では,二次性脳卒中の保護が心筋の保護よりも優先されるべきです.
- 組み合わせ治療は,血小板抑制と血管保護を最適化することによって,二次性脳卒中予防のための最良の戦略を提供することができます.
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