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対立するLSD1複合体は,発達の遺伝子活性化および抑制プログラムで機能する.

Jianxun Wang1, Kathleen Scully, Xiaoyan Zhu

  • 1Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA.

Nature
|March 30, 2007
PubMed
まとめ
この要約は機械生成です。

ヒストンデメチラーゼLSD1は,下垂体発達の過程で遺伝子の活性化と抑制を調節する. ZEB1の影響を受けたその複合体は,臓器における細胞分化と一時的な遺伝子発現パターンを調節する.

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科学分野:

  • エピジェネティクスと発達生物学
  • 遺伝子調節の分子メカニズム

背景:

  • メタゾアンの発達における転写制御は,共調節複合体と表遺伝的修正に依存する.
  • ヒストンメチルトランスフェラーゼとデメチラーゼの特定の発達の遺伝子プログラムのオーケストラ化における正確なインビボの役割は不明である.

研究 の 目的:

  • pituitary organogenesisにおけるヒストンライシンデメチラーゼLSD1の役割を調査する.
  • LSD1が,細胞系末期の決定と分化過程で,遺伝子活性化と抑制プログラムを調節する方法を解明する.

主な方法:

  • CoREST-CtBP共抑制体複合体の構成要素であるLSD1の機能を研究した.
  • LSD1の異なる共同活性化剤または共同抑制剤複合体の採用を調査しました.
  • LSD1依存遺伝子抑制に対するZEB1発現の影響を調べました.

主要な成果:

  • LSD1は,後期的な細胞系統の決定と垂体腺の分化に不可欠です.
  • LSD1は,遺伝子の活性化と抑制プログラムの両方を,異なる複雑な形成を通して調節します.
  • 発達の遅い段階で誘発されたZEB1発現は,LSD1を含む複合体を採用し,Gh. Gh. を含む追加の遺伝子を抑制します.

結論:

  • LSD1複合体のコンポーネントの時間的発現パターンは,哺乳類の臓器発達中の遺伝子調節プログラムを調節する.
  • LSD1は pituitary organogenesisにおいてダイナミックな役割を果たし,活性化機能と抑制機能を切り替える.
  • ZEB1は,後の発達段階において,LSD1媒介による遺伝子抑制を拡大する重要な調節体として作用する.