ウスティラゴの自己承認/非自己承認のための2つの構成要素の規制システムが崩壊するかもしれない
B Gillissen1, J Bergemann, C Sandmann
1Institut für Genbiologische Forschung Berlin GmbH, Federal Republic of Germany.
Cell
|February 21, 1992
まとめ
研究者らは,既知のbE遺伝子と共に,bWという第2の調節性遺伝子を,U. maydis b locusで発見した. bEとbWの遺伝子産物の相互作用は,真菌の発達の鍵となる.
科学分野:
- 菌類学 菌類学とは
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- ウスティラゴ・メイディスのマルチアレルのbロクスは,性および病原性の発達を調節する.
- 単一の調節遺伝子は以前,bロカスで特定され,そのポリペプチド製品は性発達を制御するために相互作用しました.
研究 の 目的:
- ウスティラゴ・メイディスの性および病原性発達の遺伝的基礎を調査する.
- b locus.内の追加の調節遺伝子を特定するために.
主な方法:
- U. maydis b locus. の遺伝子解析について
- 遺伝子配列とタンパク質ドメインのバイオ情報分析.
主要な成果:
- b局所における第2の調節遺伝子の識別, bWと名付け,以前に識別されたbE遺伝子とは異なる.
- bEとbWの両方の遺伝子は複数のアレルで存在し,同様の組織構造を共有しています.
- 遺伝子産物 (ポリペプチド) は,アレル特異のN端の変動性と,ホメオドメインに関連するモチーフを持つC端の保存ドメインを示します.
- 遺伝的証拠は,異なるアレルのbEとbWポリペプチドの相互作用が規制制御に不可欠であることを確認しています.
結論:
- U. maydis b locusには,bEとbWという少なくとも2つの調節遺伝子が含まれています.
- アレル固有のbEとbWポリペプチドの相互作用は,U. maydis.における性発達の主要な規制メカニズムである.
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