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Updated: May 5, 2026

A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies
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A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies

Published on: July 24, 2017

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TATA要素に対するDNA結合特異性が変化した酵母およびヒトのTFIID.

M Strubin1, K Struhl

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

Cell
|February 21, 1992
PubMed
まとめ

研究者は酵母TFIIDタンパク質を設計して,RNAポリメラーゼII転写に不可欠な変異したTATA元素を認識しました. この改変により,ヒトのTFIIDが酵母体内で機能することも可能になり,遺伝子調節における重要な相互作用が明らかになった.

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