ミコシス・ファンゴイドを合併する感染症とセザリー症候群
P I Axelrod1, B Lorber, E C Vonderheid
1Department of Medicine, Temple University School of Medicine, Philadelphia, PA.
JAMA
|March 11, 1992
まとめ
ミコシス・ファンゴイドやセザリー症候群の患者は頻繁に感染症,主に皮膚感染症を発症します. 病状の進行段階は,重篤な感染や死亡の主要なリスク因子であり,病院内感染が重大な脅威となっている.
科学分野:
- 皮膚科 皮膚科について
- 感染症 感染症は感染症です.
- 腫瘍学 腫瘍学
背景:
- ミコシス・ファンゴイド (MF) とセザリー症候群 (SS) は,著しい罹病率を有する皮膚T細胞リンパ腫である.
- 感染症は,これらの状態のために免疫システムが損なわれた患者にとって大きな懸念事項です.
研究 の 目的:
- MFとSSの患者における感染症の発生率と種類を調査する.
- ノソコミアル感染症の役割を評価し,皮膚および内臓感染症の流行病学的リスク要因を特定する.
主な方法:
- 遡及的初期コホート研究.
- MFまたはSSを患っている356人の患者の分析.
- 人口統計的および臨床的要因のための多変量リスク比率分析.
主要な成果:
- 皮膚経由の細菌感染症が最も一般的であった (17.0/100患者年).
- ノソコミアル感染症は,細菌血症 (59%),肺炎 (62%),および致死性感染症 (88%) の有意な割合を占めました.
- 皮膚外リンパ腫の関与は,重度の感染症と死亡の主なリスク因子でした.
結論:
- コミュニティで得られた細菌性皮膚感染症は一般的ですが,通常は管理可能です.
- ノソコミアルバクテレミアと肺炎は,感染症による死亡率の主な原因である.
- 病気の進行段階は,感染リスクの最も重要な予測因子です.
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