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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
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Cell Migration01:19

Cell Migration

6.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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関連する実験動画

Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

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開発は進んでいる:ヘルパーT細胞が働きかけている.

Steven L Reiner1

  • 1Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sreiner@mail.med.upenn.edu <sreiner@mail.med.upenn.edu>

Cell
|April 10, 2007
PubMed
まとめ
この要約は機械生成です。

ヘルパーT細胞 (Tヘルパー細胞) は免疫に不可欠ですが,自己免疫疾患を引き起こす可能性があります. Th17細胞系のような新しい発見は,免疫反応とその調節を理解する上で複雑さを増している.

さらに関連する動画

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

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関連する実験動画

Last Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

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科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.

背景:

  • ヘルパーT細胞は,哺乳類の病原体に対する免疫防御を指揮する上で極めて重要です.
  • 機能不全のヘルパーT細胞は,自己免疫性およびアレルギー性疾患に寄与する.
  • Th17のような新しいTヘルパー細胞系統の発見は,免疫調節の複雑さを強調しています.

研究 の 目的:

  • 免疫と自己免疫におけるヘルパーT細胞の複雑な役割を調査する.
  • 信号伝達と転写ネットワークがTヘルパー細胞の運命をどのように影響するかを理解する.
  • 適切な免疫反応と不適切な免疫反応の生成を再評価する.

主な方法:

  • T細胞の分化と機能に関する最近の発見のレビュー.
  • Tヘルパー細胞の運命決定に関与する信号伝達経路の分析.
  • 免疫反応を制御する転写ネットワークの検討.

主要な成果:

  • ヘルパーT細胞は,防御と自己免疫における二重の役割を果たします.
  • Th17系統は,Tヘルパー細胞の既知の多様性に重要な追加を示しています.
  • 信号と転写ネットワークは,免疫的結果の重要な決定因子です.

結論:

  • Tヘルパー細胞の可塑性を理解することは,免疫関連の疾患の管理に不可欠です.
  • 最近の発見は,免疫調節の概念的枠組みを再構築しています.
  • T細胞ネットワークに関するさらなる研究は,健康と病気のメカニズムを明らかにします.