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Updated: Jul 15, 2026

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

強力なピウィは,ゲノム侵入者に対して生殖系統を守ります

Kathryn A O'Donnell1, Jef D Boeke

  • 1Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cell
|April 10, 2007
PubMed
まとめ

Piwiタンパク質は,小さなRNA (piRNA) を調節し,トランポゾンを静止することによって,生殖線ゲノムの完全性にとって不可欠です. ネズミのピウィホモログミウィ2の喪失は,生殖系統の欠陥とトランスポゾン活性の増加を引き起こし,機能が保存されていることを示唆しています.

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Overview
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piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Mismatch Repair

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CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...