保存された要因は,Arabidopsis thalianaの芽と根幹細胞のオーガナイザーにおけるシグナリングを調節する
Ananda K Sarkar1, Marijn Luijten, Shunsuke Miyashima
1Institute of Biology III, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.
Nature
|April 13, 2007
まとめ
根と芽のメリステムの植物幹細胞は,同様の調節因子によって維持されます. 根のホメオボックス遺伝子WOX5と芽のWUSCHEL (WUS) は,幹細胞維持のための保存されたメカニズムを示しています.
科学分野:
- 植物生物学 植物生物学
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
背景:
- 植物の幹細胞のニッチは,根と芽のアピカルメリスタムに存在し,生涯の成長に不可欠です.
- 表面的な違いにもかかわらず,これらのニッチの共通の規制メカニズムの存在は不明のままでした.
研究 の 目的:
- 根と芽のメリステムが幹細胞の維持に関連する要因を利用しているかどうかを調査する.
- 根幹細胞のニッチ調節におけるホメオボックス遺伝子WOX5の役割を調査する.
主な方法:
- 根と芽のアピカルメリステムにおける遺伝子機能の比較分析.
- 植物根におけるWOX5遺伝子変異 (機能の喪失と獲得) の影響を調査する.
主要な成果:
- WOX5は,発芽メリスタム遺伝子WUSCHEL (WUS) の同型であり,根の静止センターで発現しています.
- WOX5機能の喪失は,根幹細胞の早めの分化につながる.
- WOX5機能の獲得は,遠端幹細胞の子孫の分化を防ぐ.
結論:
- WOX5とWUSは,根系と芽系の両方の幹細胞を維持するために関連する規制メカニズムを採用しています.
- これらの発見は,異なる植物メリステム全体で幹細胞維持のための保存されたシグナル伝達経路を示唆しています.
さらに関連する動画
09:41Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
Published on: May 14, 2020
07:52Live Cell Imaging of Microtubule Cytoskeleton and Micromechanical Manipulation of the Arabidopsis Shoot Apical Meristem
Published on: May 23, 2020
関連する概念動画
03:02Primary and Secondary Growth in Roots and Shoots
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
02:19Morphogenesis
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
01:25Cell Signaling in Plants
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
01:14Maintenance of the ES Cell State
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...