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Updated: May 19, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

肺動脈高血圧におけるフォスフォディエステラゼ1のアップレギュレーション:リバース・リモデリング療法のターゲット

Ralph Theo Schermuly1, Soni Savai Pullamsetti, Grazyna Kwapiszewska

  • 1University of Giessen Lung Centre, Justus-Liebig-Universität Giessen, Klinikstrasse 36, 35392 Giessen, Germany. ralph.schermuly@uglc.de

Circulation
|April 18, 2007
PubMed
まとめ

リンパエステラーゼ1 (PDE1) は,肺高血圧において上位調節される. PDE1を阻害することで,動物のモデルにおける血管再構築と右心疾患の逆転が起こり,PDE1が治療目標であることを示唆しています.

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