コメント "ホモ・サピエンスにおける脳サイズ決定因子であるASPMの進行中の適応的進化"
Fuli Yu1, R Sean Hill, Stephen F Schaffner
1Department of Genetics, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
まとめ
小頭症に関連したASPM遺伝子は,自然選択を受けていない可能性があります. 経験的な比較は,その変動が珍しいことではないことを示し,シミュレーションに基づく以前の発見に挑戦しています.
科学分野:
- ヒューマン・ジェネティクス ヒューマン・ジェネティックス
- 進化生物学の進化生物学について
- 集団遺伝学 人口遺伝学
背景:
- ASPM遺伝子は,小頭症 (小頭症) と関連しており,小頭症は,異常に小さな脳によって特徴づけられる状態です.
- 以前の研究によると,ASPMは過去14,100年以内に人間に自然選択を経験したことを示唆しています.
研究 の 目的:
- ASPM遺伝子に作用する自然選択の証拠を再評価する.
- ASPMの変異パターンを他の遺伝的位置と比較する.
主な方法:
- 他の遺伝子 (ロシ) の大規模なデータセットに対するASPM変異の経験的比較.
- 遺伝子変異パターンの分析.
- 以前のシミュレーションベースの分析と対比する.
主要な成果:
- ASPMの変異パターンは,多くの他の局所と経験的に比較すると,珍しいものではありません.
- 経験的なデータは,ASPMの最近の自然選択の仮説を支持しません.
結論:
- シミュレーションに基づくASPMの自然選択に関する以前の結論は不正確である可能性があります.
- 脳発達に関連する遺伝子の進化史を理解するために,さらなる調査が必要である.
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