性的アイデンティティのミステリー. 生殖細胞の視点から

Judith Kimble¹, David C Page

¹Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. jekimble@wisc.edu

Science (New York, N.Y.)

|April 21, 2007

まとめ

ソマティック信号は,動物の生殖細胞に,精子や卵になるよう指示します. 細菌細胞がこれらの信号をどのように解釈し,ミトーシスとメオシスの間を決定するかを理解することは,細菌細胞生物学の鍵です.

科学分野:

発達生物学発達生物学について
細胞生物学細胞生物学
遺伝学遺伝学とは

背景:

動物の生殖細胞は,生物の性別に基づいて精子または卵に分離します.
ソマティック細胞は,生殖細胞に環境の性別をシグナルする外部のシグナルを提供します.
生殖細胞が精子または卵になるという決定は,細胞サイクル進行,特にミトーシスとマイオシスの選択と密接に関連しています.

研究の目的:

生殖細胞が外部の体信号を解釈して,その性的アイデンティティを決定するメカニズムを調査する.
精子/卵の分化決定と,生殖細胞におけるミトーシス/メオシス細胞サイクル決定を結びつける規制論理を解明する.

主な方法:

細菌細胞の微分化のレギュレータを分析する分子研究.
生殖細胞における細胞サイクル決定 (ミトーシス対メオシス) を制御するレギュレータの調査.

主要な成果:

生殖細胞の性命決定に関与する重要な分子プレーヤーの特定.
ソマティック信号伝達経路と生殖細胞の内在的な機構の相互作用の解明.
細胞の運命と細胞サイクル決定の調整を統制する規制ネットワークの特徴.

結論:

胚性細胞の性的アイデンティティは,体的シグナルの解釈を通して確立されます.
精子/卵の決定は,ミトーシスとメオシスの両方を含む細胞サイクル機構と密接に結びついています.
細菌細胞の性発達を全面的に理解するためには,さらなる分子解剖が不可欠である.

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