関連する実験動画

Updated: Jun 22, 2026

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
05:58

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF

Published on: November 19, 2009

Zfxは,胚性および造血性幹細胞の自己再生を制御する

Jose M Galan-Caridad1, Sivan Harel, Teresita L Arenzana

  • 1Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA.

Cell
|April 24, 2007
PubMed
まとめ

転写因子Zfxは,胚性幹細胞 (ESC) と血液形成性幹細胞 (HSC) の共有レギュレータです. Zfxは,共通の標的遺伝子と特定の標的遺伝子を活性化することによって,両方の細胞タイプの自己更新を制御します.

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program11:00

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Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Lineage Commitment

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Production of Formed Elements

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Most HSCs commit to...