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Updated: Jul 15, 2026

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
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極性溶液中のピリドクサル-5'-ホスファートモデルシステムにおける低バリアおよび高バリア結合水素結合のNMR研究

Shasad Sharif1, Gleb S Denisov, Michael D Toney

  • 1Institut für Chemie und Biochemie, Takustrasse 3, Freie Universität Berlin, D-14195 Berlin, Germany.

Journal of the American Chemical Society
|April 26, 2007
PubMed
まとめ

この研究では,ピリドクサル-5'-ホスファート (PLP) モデルシステムを調査するためにNMRを使用し,水素結合がシフ基の反応性に影響する方法を明らかにしました. 陽子伝達に対する溶媒と置換剤の効果は,PLP酵素機構を理解する上で鍵となる.

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