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Updated: May 1, 2026

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function
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Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function

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核サイトプラズマタンパク質にO結合β-N-アセチルグルコサミンの循環

Gerald W Hart1, Michael P Housley, Chad Slawson

  • 1Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA. gwhart@jhmi.edu

Nature
|April 27, 2007
PubMed
まとめ

O-リンクベータ-N-アセチルグルコサミン (O-GlcNAc) は,すべての生物で動的に追加および除去され,栄養センサとして作用します. このプロセスはタンパク質シグナル伝達に影響を与え,糖尿病や神経変性などの疾患に関与しています.

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Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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Protein Folding Quality Check in the RER

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