タイの小学校の子供における症状性デング熱感染症の負担:将来的な研究

Katie B Anderson¹, Supamit Chunsuttiwat², Ananda Nisalak³

¹Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Lancet (London, England)

|May 1, 2007

まとめ

子どものデング熱による障害調整生命年 (DALY) のほとんどは,入院していない病気によるものです. デング熱を正確に評価する

科学分野:

トロピカルメディシンは,熱帯医学です.
小児感染症は,小児の感染症です.
公衆衛生の流行病学

背景:

デング熱ウイルスは,熱帯および亜熱帯地域の健康に重大な脅威をもたらします.
デング熱の完全な影響を評価することは,効果的な公衆衛生の介入に不可欠です.

研究の目的:

タイの児童におけるデング熱関連疾患の負担を将来的に評価する.
障害調整寿命年数 (DALYs) と患者費用を使用して,疾患負担を定量化します.

主な方法:

タイ北部の小学生を対象に前向きなコホート研究が行われた (1998-2002).
この研究では,DALYによるデング熱の負担と,患者一人当たりの病費を評価した.

主要な成果:

デング熱は,研究コホートにおける全発熱症例の11%を占めた.
平均的なデング熱の負担は,年間100万人あたり465.3 DALYでした.
病院に入院していないデング熱病は,毎年デング熱で失われたDALYの合計に (44-73%) 大きく貢献しました.
デング熱の血清型は,DALYsへの貢献度において異なっており,DEN2とDEN3が最大の割合を占めている.

結論:

デング熱病の負担を推定するには,入院していない症例を含めることが必要で,それらは病気の影響の重要な部分を占めています.
長期にわたる,入院しないデング熱の病気は,失われたDALYの主要な要因です.
正確なデング熱の負担の評価は,ターゲット化された公衆衛生戦略に不可欠です.

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