発作性出血におけるタルク粉による出血の安全性:前向きなコホート研究
Julius P Janssen1, Gareth Collier1, Phillippe Astoul2
1Canisius Wilhelmina Hospital, Nijmegen, Netherlands.
Lancet (London, England)
|May 8, 2007
まとめ
大粒子のタルクは,悪性膜出血の安全で効果的な治療法であり,急性呼吸困難症候群の症例は報告されていません. この研究により,縮術の手続きにおける安全性が確認されました.
科学分野:
- 肺内科 肺内科 肺内科
- 腫瘍学 腫瘍学
背景:
- タルクは,悪性内流出に対する非常に効果的な内流出剤です.
- 急性呼吸器障害症候群 (ARDS) リスク (1-9%) に関する懸念は,腹腔内タルクによる存在します.
- 大粒子のタルクの安全性を調査することは極めて重要です.
研究 の 目的:
- 発作性多発性多発性出血患者の多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発性多発症
- タルク粉を注入した後のARDSの発生率を決定する.
主な方法:
- 558人の悪性満流出症の患者を対象とした多センター前向きコホート研究です.
- 患者は胸腔鏡検査とタルク粉を4gの校正されたフランスの大粒子のタルクで施した.
- 主要エンドポイントは,プラウロデシス後のARDSの発生でした.
主要な成果:
- ARDSを発症した患者はいなかった (0%の発生率).
- 11人の患者 (2%) が30日以内に死亡しました.
- 7人の患者 (1.2%) は,呼吸器不全の1例を含む,致命的でない合併症を経験しました.
結論:
- 大粒子のタルクの使用は,悪性気流における気流の治療に安全である.
- 大粒子のタルクはARDSの発生と関連していません.
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