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Updated: May 1, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

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薬剤排出ステントの非表示および未試験使用に関連するアウトカムと合併症

Nirat Beohar1, Charles J Davidson, Kevin E Kip

  • 1Northwestern University Feinberg School of Medicine, Chicago, Ill, USA. n-beohar@northwestern.edu

JAMA
|May 10, 2007
PubMed
まとめ

薬剤排出ステント (DES) の非標識および未試験使用は,皮膚経冠動脈介入 (PCI) で一般的です. オフレーベルDESの使用では早期の安全性が低いが,オフレーベルおよび未試験の indikationsの両方で長期的な有効性は低下しているが,絶対的なイベント率は低いままである.

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Modified-Release Drug Delivery Systems: Classification01:23

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