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ディスルフィドイソメラーゼによる腫瘍関連NKG2Dリガンドの脱落を促す

Brett K Kaiser1, Daesong Yim, I-Ting Chow

  • 1Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

Nature
|May 15, 2007
PubMed
まとめ

腫瘍は,細胞表面ERp5.5によって促進されるMICAリガンドの流出によって免疫攻撃を回避する. ERp5を阻害すると,MICAの分泌を阻害し,新たながん治療の標的となる.

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