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Updated: Jul 14, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
14:25

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain

Published on: December 12, 2017

グアニジニウム塩化物と尿素の水溶液における水害性およびイオン性溶液間の相互作用:タンパク質の変性化機構に関する教訓

Edward P O'Brien1, Ruxandra I Dima, Bernard Brooks

  • 1Biophysics Program, Institute for Physical Science and Technology, Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.

Journal of the American Chemical Society
|May 17, 2007
PubMed
まとめ

グアニジニウム塩化物や尿素のようなデナチュラントによるタンパク質展開は,主に直接の相互作用によって起こります. これらのデナチュラントは,電荷の残留物を溶解したり,水素結合を形成して,タンパク質の構造に影響を与えることによって,静電相互作用を変化させます.

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