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Helicobacter pylori CagAはPAR1/MARKキナーゼを標的とし,上皮細胞の極性を破壊する

Iraj Saadat1, Hideaki Higashi, Chikashi Obuse

  • 1Division of Molecular Oncology, Institute for Genetic Medicine, Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan.

Nature
|May 18, 2007
PubMed
まとめ

ヘリコバクター・パイロリCagAタンパク質は,PAR1キナーゼを阻害することによって,胃上皮細胞の極性を破壊する. この相互作用は細胞の伸びを促進し,胃疾患の発症に貢献します.

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