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Updated: Jun 30, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

染色体不安定のマウス腫瘍は,ヒトの様々ながんに似たゲノム変異がある

Richard S Maser1, Bhudipa Choudhury, Peter J Campbell

  • 1Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Nature
|May 23, 2007
PubMed
まとめ

遺伝的に不安定なマウスモデルは,がん遺伝子の発見に役立ちます. これらのモデルは,マウスリンパ腫とヒトT細胞急性リンパ性白血病/リンパ腫 (T-ALL) でのFBXW7およびPTEN消去のような一般的な遺伝イベントを特定し,種間がんの類似性を強調しました.

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