ヘモグロビン変種と重症のファルシパラムマラリアにおける疾患の表れ
Jürgen May1, Jennifer A Evans, Christian Timmann
1Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
JAMA
|May 24, 2007
まとめ
ヘモグロビンS (HbS) キャリアステータスは,すべての重度のマラリア形態から保護します. ヘモグロビンC (HbC) とアルファ+タラセミア (-アルファ) キャリア状態は,それぞれ脳マラリアと重度の貧血に対してのみ保護を提供します.
科学分野:
- 遺伝学と人間の進化について
- 感染症 感染症は感染症です.
- 血液学 ヘマトロジ
背景:
- ヘモグロビンS (HbS),ヘモグロビンC (HbC),アルファ+タラセミア (-アルファ) の地理的分布は,選択とマラリアのバランスをとることを示唆しています.
- マラリアに対するHbSのキャリア状態の保護は確立されているが,HbCと-alphaの証拠は,特に特定の疾患形態に関して,決定的ではない.
研究 の 目的:
- 重度のファルシパラムマラリアとHbS,HbC,および-alpha.のキャリア状態との関連を調査する.
主な方法:
- 重度のファルシパラムマラリアを患った2591人の子どもと,西アフリカのガーナで,マラリアを患った2048人の子どもを対象とした症例対照研究が行われました.
- 患者および対照群におけるHbS,HbC,および-alphaの遺伝子型頻度の分析.
- 重度の病気の臨床的徴候によるマラリア患者の階層化.
主要な成果:
- HbSのキャリア状態は,すべての研究された重症マラリア形態 (OR,0.08) と有意な負の関連を示した.
- HbCキャリア状態は,脳マラリアのリスクの低下と選択的に関連していました (OR,0.64).
- -α キャリアの状態は,選択的に重度の貧血のリスクの低下と関連していました (OR,0.82).
結論:
- HbSのキャリア状態は,重度のファルシパラムマラリアに対する広範な保護を提供します.
- HbCおよび-α キャリア状態は,それぞれ,脳マラリアおよび重度の貧血に対する特定の保護を提供します.
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