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Updated: Jul 7, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

アブラキサスとRAP80は,DNA損傷反応に必要なBRCA1タンパク質複合体を形成しています

Bin Wang1, Shuhei Matsuoka, Bryan A Ballif

  • 1Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|May 26, 2007
PubMed
まとめ

研究者らは,BRCA1に結合し,RAP80.0.を募集するのに役立つタンパク質であるAbraxasを発見しました. この複合体は,DNA損傷抵抗性,細胞サイクル制御,DNA修復に不可欠であり,BRCA1を助けます.

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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

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Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

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DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

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