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Updated: Jul 14, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

RAP80は,BRCA1をDNA損傷部位の特定のユビキチン構造に標的とする

Bijan Sobhian1, Genze Shao, Dana R Lilli

  • 1Dana-Farber Cancer Institute and Department of Genetics and Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

Science (New York, N.Y.)
|May 26, 2007
PubMed
まとめ

研究者らは,BRCA1タンパク質がDNA損傷部位に結合する方法を発見した. RAP80タンパク質は,DNA修復と細胞サイクルチェックポイントにおいて極めて重要な二重鎖断裂 (DSB) で,BRCA1をユビキチン鎖に標的にする.

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gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

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