Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
The Synapse02:47

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Neuronal Communication01:28

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Bioelectricity Buzz.

Bioelectricity·2026
Same author

A randomized controlled trial comparing remote blood pressure monitoring with office-based blood pressure monitoring for women at high risk of preeclampsia.

American journal of obstetrics and gynecology·2026
Same author

Cannabinoid CB<sub>1</sub> receptors drive oligodendrocyte maturation during myelin regeneration.

Cell communication and signaling : CCS·2026
Same author

Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing.

Nature communications·2026
Same author

Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation.

Frontiers in synaptic neuroscience·2026
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

関連する実験動画

Updated: Jun 25, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

脳の配線:エンドカンナビノイドはニューロンの接続性を形作ります.

Paul Berghuis1, Ann M Rajnicek, Yury M Morozov

  • 1Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden.

Science (New York, N.Y.)
|May 26, 2007
PubMed
まとめ
この要約は機械生成です。

エンドオカンナビノイドは,脳の発達中に重要な軸索誘導信号として作用します. 彼らは,カンナビノイド受容体 (CB1Rs) を活性化して,シナプトゲネシスに影響を与え,特定のニューロンの成長と標的選択を調節します.

さらに関連する動画

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software
07:45

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software

Published on: September 27, 2024

関連する実験動画

Last Updated: Jun 25, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software
07:45

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software

Published on: September 27, 2024

科学分野:

  • 神経科学は神経科学である.
  • 発達生物学 発達生物学について
  • 細胞生物学 細胞生物学

背景:

  • 中枢神経系の発達におけるエンドカンナビノイドシグナル伝達の役割は,依然としてほとんど未調査のままである.
  • 神経発達を理解することは,神経学的障害に対処するために重要です.

研究 の 目的:

  • 中枢神経系の発達におけるエンドカンナビノイド信号伝達の機能を調査する.
  • 神経細胞の発達とシナプトゲネシスにおけるカンナビノイド受容体1 (CB1R) の役割を決定する.

主な方法:

  • 歯類モデルとXenopus laevisを用いて,軸索の成長コンと神経細胞の発達を研究した.
  • GABAergicインターニューロンにおけるCB1Rsの局所化と機能を調査した.
  • RhoA活性化アッセイとギャルバノトロピズム実験を使用して,成長コンの形態学とニューロンの誘導に対するエンドカンナビノイドの影響を調査しました.

主要な成果:

  • CB1Rsは,歯類の皮質の発達中のGABAergicインターニューロンの軸索成長で濃縮されています.
  • エンドカンナビノイドはCB1Rの内部化を誘導し,RhoAを活性化させ,成長コンの崩壊と化学排斥につながる.
  • エンドオカンナビノイドは,Xenopusの脊髄ニューロンにおけるガルバノトロピズムを阻害する.
  • CB1Rsが欠けているマウスは,皮質のGABAergicインターニューロンの標的選択の障害を示します.

結論:

  • エンドカンナビノイドは,中枢神経系の発達中に重要な軸索誘導信号として機能します.
  • エンドカンナビノイドシグナリングは,シナプトゲネシスとターゲット選択を vivo で調節します.
  • CB1Rシグナリングは,発達中の脳の適切な配線に不可欠です.