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関連する概念動画

Mismatch Repair01:36

Mismatch Repair

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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関連する実験動画

Updated: Jul 11, 2026

A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

繰り返し発生するストレスによる怪我

Maurits van Tulder1, Antti Malmivaara2, Bart Koes3

  • 1Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, Netherlands; Institute of Health Sciences, Faculty of Earth & Life Sciences, VU University, Amsterdam, Netherlands.

Lancet (London, England)
|May 29, 2007
PubMed
まとめ

繰り返しストレスの損傷 (RSI) の診断には,強力なイメージングの証拠が欠如しており,効果的な治療は主に短期的な疼痛緩和を提供します. 運動は,非特異的な上肢疾患に有益であることが示されており,特定の疾患は,ターゲットを絞った介入が示されています.

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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

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Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

関連する実験動画

Last Updated: Jul 11, 2026

A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

科学分野:

  • 整形外科 整形外科 整形外科
  • 職業医学は職業医学である.
  • リハビリテーション医学 リハビリテーション医学

背景:

  • RSI (リピティティブ・ストレス・インジメーション) は,上肢の様々な障害を網羅し,しばしば臨床的に診断されます.
  • RSIの診断のための高品質のイメージング研究 (MRI,超音波) は限られており,その役割は不明である.
  • 上肢障害に対する治療の有効性に関する証拠はほとんどなく,主に短期的な疼痛緩和が観察されています.

研究 の 目的:

  • 繰り返しのストレスの傷害の診断と治療に関する現在の証拠をレビューする.
  • 上肢障害の診断における高度なイメージングの役割を評価する.
  • 異なるタイプのRSIに対する様々な介入の有効性を評価する.

主な方法:

  • 繰り返しのストレスの傷害に関する既存の文献の体系的なレビュー.
  • MRIや超音波を用いた診断精度試験の分析,MRIや超音波を用いた診断精度試験の分析
  • 上肢障害に対する治療効果を評価するランダム化比較試験の評価.

主要な成果:

  • 臨床診断はRSIの標準ですが,高品質のイメージングの証拠は不足しています.
  • 運動は,非特異的な上肢疾患に有益である.
  • 特定の治療は,手足トンネル症候群 (ブレスレット,手術) と側頭上皮質炎 (NSAID,注射) のような状態に対して有効性を示しています.
  • 運動とコルチコステロイド注射は,それぞれ首と肩の痛みに役立ちます.

結論:

  • 労働人口と労働関連の結果に焦点を当てたさらなる高品質の試験が必要です.
  • 繰り返しのストレスの傷害に対する介入の有効性は,しばしば限られ,短期的です.
  • ターゲットを絞った治療は,特定の上肢の疾患に緩和をもたらすが,非特定の疾患は運動から恩恵を受ける.