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関連する概念動画

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton08:50

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

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In this work, an in vitro reconstitution approach is employed to study the poroelasticity of actomyosin gels under controlled conditions. The dynamics of the actomyosin gel and the embedded solvent are quantified, through which the network poroelasticity is demonstrated. We also discuss the experimental challenges, common pitfalls, and relevance to cell cytoskeleton...
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Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

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This protocol presents a method to perform rheology characterization of mucus that resides on gill rakers (GRs) of the silver carp. Viscoelastic characteristics of GR-mucus, obtained by measuring viscosity, storage and loss moduli, are evaluated for the apparent yield stress to understand the filter feeding mechanism in...
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The Diffusion of Passive Tracers in Laminar Shear Flow08:01

The Diffusion of Passive Tracers in Laminar Shear Flow

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A protocol for the study of the diffusion of passive tracers in laminar pressure-driven flow is presented. The procedure is applicable to various capillary pipe...
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Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

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Two different methods for characterizing the incipient particle motion of a single bead as a function of the sediment bed geometry from laminar to turbulent flow are...
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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

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An experimentally accessible analog method for studying molecular hydrodynamic processes in dense fluids is presented. The technique uses particle image velocimetry of vibrated, high-restitution grain piles and allows direct, macroscopic observation of dynamical processes known and predicted to exist in strongly interacting, high density gases and...
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Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

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Confocal microscopy is used to image quiescent and flowing colloid-polymer mixtures, which are studied as model systems for attractive suspensions. Image analysis algorithms are used to calculate structural and dynamic metrics for the colloidal particles that measure changes due to geometric...
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関連する実験動画

Updated: Jan 13, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

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2つのニューロンは,C. elegansの食事制限による長寿を媒介する.

Nicholas A Bishop1, Leonard Guarente

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|June 1, 2007
PubMed
まとめ

食事制限は,特定のニューロンのskn-1遺伝子を活性化することによって寿命を延ばします. これは,代謝を促進するために他の体組織にシグナルを送り,長寿への神経のリンクを証明します.

科学分野:

  • 細胞生物学 細胞生物学
  • 神経科学は神経科学である.
  • 遺伝学 遺伝学とは

背景:

  • ダイエット制限 (DR) は,種ごとに寿命を延ばし,老化を遅らせることが知られている.
  • DRは哺乳類の内分泌機能に重大な影響を及ぼしますが,長寿への直接的なホルモン関連は未だ証明されていません.
  • DRが長寿に影響を与える分子メカニズムは完全に理解されていません.

研究 の 目的:

  • ダイエット制限による長寿におけるホルモン信号の因果的役割を調査する.
  • DR媒介による寿命延長に関与する特定の遺伝子と細胞経路を特定する.
  • DRに対する反応としてニューロンと周辺組織間のコミュニケーションメカニズムを解明する.

主な方法:

  • 寿命研究のためにモデル生物であるCaenorhabditis elegansを使用した.
  • 転写因子遺伝子skn-1とASIニューロンにおけるその役割に焦点を当てた.
  • 神経細胞から外周組織への信号伝達経路を調査した.

主要な成果:

  • C. elegansの食事制限による長寿には,転写因子遺伝子skn-1が必要である.
  • skn-1はASIニューロン,頭の中の感覚ニューロンのペアの中で作用します.

さらに関連する動画

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

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関連する実験動画

Last Updated: Jan 13, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

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Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

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  • DRは,ASIニューロン内のskn-1を活性化させ,その後,外周組織に信号を送り,代謝活動を増加させます.

    • 結論:

    • 食事制限のメタゾアンの寿命の延長は,細胞の非自律的なシグナル伝達に依存しています.
    • ASIニューロンは,skn-1を含む内分泌機構を通じてDR誘発の長寿を媒介する.
    • この研究は,DR長寿における特定の神経信号伝達経路の因果的な役割を実証しています.