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Updated: Jul 9, 2026

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Published on: July 29, 2010

TLR誘発の染色体変異による炎症の遺伝子特異的制御

Simmie L Foster1, Diana C Hargreaves, Ruslan Medzhitov

  • 1Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06405, USA.

Nature
|June 1, 2007
PubMed
まとめ

トール型受容体 (TLR) のシグナル伝達が炎症を誘発しますが,この研究は遺伝子特異的な調節を明らかにしています. マクロファージは,炎症性および抗微生物性遺伝子を制御するために,異なるクロマチンの改変を使用し,適応性免疫反応を可能にします.

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