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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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孤独な心房細動の患者における老化による長期的な進行とアウトカム: 30年間の追跡調査
Arshad Jahangir1, Victor Lee, Paul A Friedman
1Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Circulation
|June 6, 2007
まとめ
孤独な心房細動 (AF) が永久的なAFへと進行することは一般的ですが,長期的な生存率は一般の人々と似ています. 高血圧のような併発性疾患は,AF患者の脳卒中リスクを高めます.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- クリニカル・メディシン 臨床医学
背景:
- 孤独な心房細動 (AF) の長期的な自然史は,ほとんど不明のままです.
- 進行と長期的な合併症を理解することは,患者の管理に不可欠です.
研究 の 目的:
- 30年以上にわたってパラキシズマルのAFから永久的なAFへの進行速度と予測要因を決定する.
- 心不全,血栓栓塞栓症,および死亡の長期的なリスクを評価するために,対照群と比較して単独のAF患者で.
主な方法:
- ミネソタ州オルムステッド郡で1950年から1980年の間に診断された単発性AF (パラキズム性,持続性,または永久性) の76人の患者を長期追跡した.
- 生存率,永続的なAFへの進行,心不全および血栓塞栓性イベントの発生率は,年齢と性別をマッチした対照群と比較されました.
主要な成果:
- 30年以上にわたり,パーオキシズム性または持続的な単発性AFを患っていた71人の患者のうち22人が,永久的なAFに進行した.
- 総生存率は一般人口と同等であったが,心不全のない生存率はわずかに悪化した.
- 卒中や一時的な血栓塞栓症を含む血栓栓塞栓のリスクは,特にリスク要因を発症した患者で25年後に増加しました.
結論:
- 併発症は,心房細動の進行および合併症に大きく影響する.
- 高齢化と高血圧の発症は,単独のAF患者における血栓塞栓のリスクを高める重要な要因です.
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