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Updated: Jun 20, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

DNA修復は,老化中の血液形成性幹細胞を制限しています

Anastasia Nijnik1, Lisa Woodbine, Caterina Marchetti

  • 1Henry Wellcome Building for Molecular Physiology, Oxford University, Oxford OX3 9DU, UK.

Nature
|June 8, 2007
PubMed
まとめ

DNA損傷の修復は,幹細胞の老化に不可欠です. マウスの特定のDNAリガゼIV変異は,DNA二重鎖の破裂修復が損なわれ,幹細胞の枯渇と老化を加速することを明らかにした.

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