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Updated: Jul 3, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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Akt/PKBは,PGC-1αトランスクリプションコアクティベーターを直接抑制することによって,肝臓の代謝を調節する

Xinghai Li1, Bobby Monks, Qingyuan Ge

  • 1Institute for Diabetes, Obesity and Metabolism, Cox Institute, University of Pennsylvania School of Medicine and the Howard Hughes Medical Institute, Philadelphia, Pennsylvania 19104, USA.

Nature
|June 8, 2007
PubMed
まとめ

2型糖尿病におけるインスリン抵抗性は,脂質代謝を損なう. この研究は,インスリンがAkt2経由でPGC-1αを抑制し,肝臓の脂質合成を制御し,新しい治療標的を提供する方法を示しています.

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