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Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Updated: May 12, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

冠動脈のカルシフィケーションの進行は遺伝性である.

Andrea E Cassidy-Bushrow1, Lawrence F Bielak, Patrick F Sheedy

  • 1Department of Epidemiology, University of Michigan, 611 Church St, Ann Arbor, MI 48104-3028, USA.

Circulation
|June 15, 2007
PubMed
まとめ

遺伝的要因は,冠動脈結石化 (CAC) の進行を著しく影響する. 初期CACに影響する多くの遺伝子は,その進歩にも影響し,動脈硬化症の遺伝的構造を強調しています.

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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

関連する実験動画

Last Updated: May 12, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

科学分野:

  • 心血管遺伝学 心血管遺伝学
  • メディカルイマージング (医学イメージング)
  • バイオ統計学 バイオ統計学

背景:

  • 冠動脈結石化 (CAC) は冠動脈動脈硬化症の重要な指標である.
  • 電子ビームコンピューティングトモグラフィーは,正確で非侵襲的なCAC測定と連続進行量化を可能にします.
  • CACの進行における遺伝子の役割は,ほとんど未知のままです.

研究 の 目的:

  • CACの進行に対する遺伝的および環境的要因の貢献を定量化する.
  • ベースラインのCACと進行の間の遺伝的相関を調査する.

主な方法:

  • シリアルCAC測定のための電子ビームコンピュータトモグラフィーを利用し,625の家族から877人の成人を対象とした.
  • 遺伝性と遺伝的相関を推定するために統計モデルを使用し,リスク要因とベースラインCACを調整しました.

主要な成果:

  • CAC進行の遺伝性は0.40と推定され,重要な遺伝的影響を示しています.
  • 遺伝的要因は,CAC進行の変動の14%を占めました.
  • ベースラインのCAC量と進行の間の強い遺伝的相関 (0.80) が観察されました.

結論:

  • 遺伝的要因は,CAC.の初期存在と進行の両方において重要な役割を果たします.
  • 共通の遺伝的影響は,冠動脈動脈硬化症の遺伝的構造を理解することの重要性を強調しています.
  • 特定の遺伝因子に関するさらなる研究は,疾患のメカニズムと潜在的な治療目標についての洞察を提供することができます.