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Updated: May 5, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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焦点粘着キナーゼの自己抑制のための構造的基礎

Daniel Lietha1, Xinming Cai, Derek F J Ceccarelli

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|June 19, 2007
PubMed
まとめ

焦点粘着キナーゼ (FAK) は,そのFERMドメインによって調節され,キナーゼ活性を抑制します. 構造分析は,FAKの活性化がFERMの移位とリン酸化を伴うことを明らかにし,細胞シグナル伝達を可能にします.

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