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Updated: May 5, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

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限定的な家族構造とBRCA遺伝子変異の状態が,乳がんの単一の症例で認められる

Jeffrey N Weitzel1, Veronica I Lagos, Carey A Cullinane

  • 1Department of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA. jweitzel@coh.org

JAMA
|June 21, 2007
PubMed
まとめ

家族構造は,遺伝性乳がんリスクに影響します. 限定的な家族歴は,BRCA遺伝子変異の流行率を増加させ,早期発症の乳がん症例の遺伝子検査ガイドラインを更新する必要があることを示唆しています.

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