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Testing Animal Anxiety in Rats: Effects of Open Arm Ledges and Closed Arm Wall Transparency in Elevated Plus Maze Test
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ロシグリタゾン試験のデータと安全性モニタリング

Elizabeth G Nabel, Susan B Shurin, Denise G Simons-Morton

    Lancet (London, England)
    |June 26, 2007
    PubMed
    まとめ

    No abstract available in PubMed .

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    Toxicity Testing in Animals01:23

    Toxicity Testing in Animals

    Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...