関連する実験動画

Updated: Jul 12, 2026

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
12:15

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging

Published on: October 3, 2017

Rab8 GTPaseは,腸内細胞におけるアピカルタンパク質の局所化を調節する

Takashi Sato1, Sotaro Mushiake, Yukio Kato

  • 1Laboratory of Molecular Traffic, Department of Molecular and Cellullar Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan.

Nature
|June 29, 2007
PubMed
まとめ

Rab8タンパク質は,小腸内の正しいアピカルタンパク質の局所化に不可欠です. その欠乏は,栄養素の吸収不良とアピカルタンパク質の分解を引き起こし,深刻な健康被害をもたらします.

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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

Imaging ATG9A, a Multi-Spanning Membrane Protein07:20

Imaging ATG9A, a Multi-Spanning Membrane Protein

Published on: June 16, 2023

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Coat Assembly and GTPases01:33

Coat Assembly and GTPases

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Rab Proteins

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Protein Folding Quality Check in the RER

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Rab Cascades

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Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

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Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...