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Updated: May 12, 2026

Chromatin Immunoprecipitation from Human Embryonic Stem Cells
10:36

Chromatin Immunoprecipitation from Human Embryonic Stem Cells

Published on: July 22, 2008

プラリポテンツ細胞および系統にコミットした細胞におけるクロマチンの状態の全ゲノム地図

Tarjei S Mikkelsen1, Manching Ku, David B Jaffe

  • 1Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

Nature
|July 3, 2007
PubMed
まとめ

この研究では,単一分子配列を解析して,全ゲノムにわたるヒストンの改変をマッピングし,これらのマークが哺乳類の細胞状態と遺伝子調節をどのように定義するかを明らかにしています.

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Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...
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Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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